Int J Gynecol Cancer. 1992 May; 2(3): 163-167.
Lactic acidosis and hypoglycemia: a metabolic complication of advanced gynecologic malignancy.
Department of Obstetrics and Gynecology, Brigham & Women's and Beth Israel Hospitals, Harvard Medical School, Boston, Massachusetts, USA.
Refractory lactic acidosis and hypoglycemia characterize a paraneoplastic syndrome observed in advanced gynecologic cancer, as illustrated by a patient with a large malignant mixed Mullerian tumor. Massive infusions of sodium bicarbonate and glucose failed to reverse her metabolic abnormalities, and the patient suffered a rapidly fatal course. The biochemical basis for this metabolic complication is reviewed, including how medical intervention can lead to iatrogenic exacerbation of the metabolic imbalance.
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