Jpn J Pharmacol. 1992 Nov; 60(3): 303-5.

Effects of nitric oxide synthase inhibitors on gastric alkaline secretion in rats.

Takeuchi K, Ohuchi T, Miyake H, Sugawara H, Okabe S.

Department of Applied Pharmacology, Kyoto Pharmaceutical University, Japan.

The effects of NG-nitro-L-arginine methyl ester (L-NAME), the nitric oxide (NO) synthase inhibitor, on gastric HCO3- secretion were examined in anesthetized rats. Intravenous administration of L-NAME (1, 2.5, 5 mg/kg) increased HCO3- secretion in a dose-related manner. This effect of L-NAME was mimicked by NG-mono-methyl-L-arginine (50 mg/kg, i.v.) and was antagonized significantly by concurrent administration of L-arginine but not D-arginine (200 mg/kg, i.v.). These results indicate that gastric HCO3- secretion is stimulated by inhibition of NO biosynthesis.

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