Antonie Van Leeuwenhoek. 1992 Nov; 62(4): 319-20.
Effects of some tricyclic psychopharmacons and structurally related compounds on motility of Proteus vulgaris.
Institute of Microbiology, Albert Szent-Gyorgyi Medical University, Szeged, Hungary.
A simple test for the evaluation of drugs interfering with bacterial motility was established with Proteus vulgaris. With this model, promethazine, 7-hydroxy-chlorpromazine, imipramine, 7,8-dioxochlorpromazine and acridine orange were shown to exert significant motility and swarming inhibitory action on Proteus vulgaris strains at subinhibitory concentrations. Quinidine enhanced the antimotility effect of promethazine. The antimotility effect of promethazine was synergized by proton pump inhibitors omeprazole and abscissic acid, but antagonized by extracellular potassium and sodium ions.
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